Table 3 Univariate and multivariate Cox regression model for PFS in CRLM
Characteristic | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
HR (95%CI) | p-value | HR (95%CI) | p-value | |
Sex (female vs. male) | 1.247 (0.810, 1.921) | 0.316 | ||
Age (year) | 0.992 (0.975, 1.010) | 0.379 | ||
Time of finding CRLM (synchronous vs. metachronous) | 0.998 (0.587, 1.696) | 0.993 | ||
Number of CRLM | 1.093 (1.013, 1.179) | 0.022 | ||
Size of largest CRLM (mm) | 1.007 (0.996, 1.019) | 0.232 | ||
Primary tumor site (colon vs. rectum) | 1.327 (0.851, 2.067) | 0.212 | ||
T-stage of primary tumor (1–2 vs. 3–4) | 1.266 (0.584, 2.746) | 0.550 | ||
N-stage of primary tumor (0–1 vs. 2) | 1.509 (0.935, 2.433) | 0.092 | ||
Genetic mutation (no vs. yes) | 1.356 (0.824, 2.231) | 0.232 | ||
Treatment before surgery (chemotherapy vs. with target therapy) | 1.141 (0.751, 1.734) | 0.536 | ||
Use RFA in surgery (no vs. yes) | 1.473 (0.795, 2.731) | 0.218 | ||
Chemotherapy after surgery (no vs. yes) | 0.597 (0.329, 1.084) | 0.090 | 0.461 (0.244, 0.871) | 0.017 |
With extrahepatic metastases (no vs. yes) | 0.783 (0.413, 1.483) | 0.453 | ||
Preoperative CEA (ng/ml) | 1.001 (1.000, 1.001) | 0.015 | 1.001 (1.000, 1.001) | 0.006 |
MH (yes vs. no) | 2.269 (1.380, 3.732) | 0.001 | 2.521 (1.484, 4.284) | 0.001 |