Fig. 3

The images depict a case of non-SMAD4-mutated PDAC located in the head of the pancreas with a CA19-9 level of 61.8 U/mL. The series includes unenhanced transverse images(a), contrast-enhanced images in the arterial phase (b), venous phase(c), and delayed phase (d) T1W images, illustrating a 3.3-cm low-signal-intensity mass without rim enhancement (arrows). (e) MRCP illustrates dilation-free of the CBD. (f) SMAD4 immunostaining reveals intense expression within the nuclei of the tumor cells (scale bar = 30 μm)