Prediction of neoadjuvant chemotherapy efficacy in breast cancer: integrating multimodal imaging and clinical features

Chen, Xianglong; Luo, Yong; Xie, Zhiming; Wen, Yun; Mou, Fangsheng; Zeng, Wenbing

doi:10.1186/s12880-025-01631-2

Table 6 Analysis of the correlation and diagnostic performance between quantitative and semi-quantitative parameters of DCE-MRI, as well as global histogram parameters of DKI and IVIM, and the non-significant efficacy of neoadjuvant chemotherapy (NAC) in breast cancer

From: Prediction of neoadjuvant chemotherapy efficacy in breast cancer: integrating multimodal imaging and clinical features

	Correlation coefficient (rs)^a	AUC	95%CI	Sensitivity (%)	Specificity (%)	PPV	NPV	Accuracy
DCE-Kep	-0.227	0.632	0.515–0.739	76.47	51.16	0.553	0.733	0.623
DCE-Ve	0.267	0.647	0.530–0.753	85.29	44.19	0.547	0.791	0.623
DKI-D-90Percentile	-0.299	0.674	0.557–0.776	50.00	81.40	0.680	0.673	0.675
DKI-D-Max	-0.357	0.707	0.593–0.805	67.65	72.09	0.657	0.738	0.701
DKI-D-Mean	-0.284	0.665	0.548–0.768	41.18	90.7	0.778	0.661	0.688
DKI-D-Median	-0.290	0.669	0.552–0.772	50.00	83.72	0.708	0.679	0.688
DKI-D-Range	-0.357	0.707	0.593–0.805	73.53	69.77	0.657	0.769	0.714
DKI-K-Mean	0.386	0.724	0.611–0.820	70.59	67.44	0.631	0.743	0.688
DKI-K-Median	0.337	0.696	0.580–0.795	58.82	81.40	0.714	0.714	0.714
IVIM-D-90Percentile	-0.317	0.684	0.568–0.785	88.24	46.51	0.566	0.833	0.649
IVIM-D-Entropy	0.239	0.639	0.522–0.746	47.06	79.07	0.640	0.653	0.649
IVIM-D-InterquartileRange	-0.339	0.697	0.582–0.797	94.12	41.86	0.561	0.900	0.649
IVIM-D-Kurtosis	0.250	0.645	0.528–0.751	58.82	67.44	0.588	0.674	0.636
IVIM-D-Mean	-0.367	0.713	0.559–0.811	64.71	79.07	0.709	0.739	0.727
IVIM-D-Median	-0.313	0.682	0.556–0.783	44.12	90.70	0.789	0.672	0.701
IVIM-D-Skewness	0.224	0.630	0.513–0.738	55.88	76.74	0.655	0.687	0.675
IVIM-D-Uniformity	-0.256	0.642	0.525–0.748	41.18	81.40	0.636	0.636	0.636
IVIM-D-Variance	-0.287	0.667	0.550–0.770	85.29	51.16	0.579	0.814	0.662
IVIM-f-Entropy	0.247	0.644	0.526–0.750	79.41	46.51	0.539	0.740	0.610
IVIM-f-InterquartileRange	-0.296	0.672	0.556–0.775	52.94	81.40	0.692	0.686	0.688
DCE		0.676	0.560–0.778	91.18	37.21	0.534	0.842	0.610
DKI		0.826	0.722–0.903	70.59	90.70	0.857	0.795	0.818
IVIM		0.885	0.792–0.947	100.00	62.79	0.679	1.000	0.792
DKI + IVIM		0.950	0.875–0.987	91.18	88.37	0.861	0.926	0.896
DCE + DKI + IVIM		0.969	0.901–0.995	94.12	90.70	0.888	0.951	0.922

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