Table 1 The diagnostic criteria for ACAs classification

NAA

1.The pathological diagnosis is ACAs.

2.Non-functional (normal blood biochemistry markers associated with functional adenomas)

CPA

1.The pathological diagnosis is ACAs.

2.The 24-hour serum cortisol level is greater than 113.35 mmol/L (4.1 µg/dL).

3.The morning 8 a.m. adrenocorticotropic hormone (ACTH) level is less than 3.0 pmol/L (13.63 pg/mL).

4.Clinical exclusion of other categories

APA

1.The pathological diagnosis is ACAs.

2.History of hypertension and hypokalemia associated with APA.

3.ARR, based on renin activity: ARR > 30 (ng/dL) / (ng·mL⁻¹·h⁻¹); based on renin concentration: ARR > 37 (mU/L) / (ng/dL).