Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas

Table 1 Participant demographic, clinical, and pathological characteristics

Characteristic	IDH-wildtype (n = 33)	IDH-mutant (n = 30)		p
Characteristic	IDH-wildtype (n = 33)	1p19q-intact (n = 22)	1p19q-codel (n = 8)	p
Age (years)	57.5 (50–64)	36 (32–46)	45 (35–47)	< 0.001^**
Sex (male/female)	17/16	12/10	4/4	0.469
KPS	80 (50–90)	80 (70–90)	90 (90–90)	0.038^*
Recurrent/primary glioma	7/26	6/16	2/6	0.845
WHO CNS5 subtype
Glioblastoma	28	NA	NA	NA
Astrocytoma (grade 2/3/4)	NA	13/4/5	NA	NA
Oligodendroglioma (grade 2/3)	NA	NA	6/2	NA
Ki-67 LI (%)	32.5 (12.5–50)	10 (5–30)	5 (4.5–10)	0.002^**

Values are presented as number or median (interquartile range). ^*p < 0.05 and ^**p < 0.01. IDH = isocitrate dehydrogenase, 1p19q-codel = synchronous deletion of the short arm of chromosome 1 and long arm of chromosome 19, KPS = Karnofsky performance status, WHO CNS5 = fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System, NA = not applicable, Ki-67 LI = Ki-67 labeling index

ISSN: 1471-2342