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Table 2 Comparisons of DDVD and IVIM parameter values of whole TP between glioma groups

From: Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas

Metric

IDH-wildtype (n = 33)

IDH-mutant (n = 30)

Z

p

Glioblastoma (n = 28)

Astrocytoma (n = 22)

Oligodendroglioma (n = 8)

Z

p#

DDVD

         

 DDVDb0b10_b10b20

14.48(12.93–18.60)

12.76(9.79–14.60)

-2.849

0.008**

14.22(13.07–18.38)

12.71(9.77–14.60)

12.76(10.50-15.21)

-2.697

0.014*

 DDVDb0b10

17.72(14.67–22.63)

17.89(13.58–20.83)

-1.046

0.296

17.94(14.72–22.52)

17.89(13.51–20.75)

17.53(15.10-21.75)

-1.075

0.282

 nDDVDb0b10_b10b20

20.55(15.89–24.02)

15.14(11.61–19.29)

-3.578

< 0.001**

20.33(16.59–23.89)

15.26(11.41–19.29)

14.66(12.50-19.44)

-3.342

0.006**

 nDDVDb0b10

24.84(17.97–27.03)

21.10(16.09–25.24)

-1.830

0.080

24.15(18.64–26.55)

21.10(14.90-24.99)

19.82(17.17–27.20)

-1.759

0.119

IVIM

         

 IVIM_D

1.16(0.98–1.27)

1.31(1.19–1.39)

-3.358

0.003**

1.19(0.97–1.29)

1.32(1.18–1.40)

1.28(1.21–1.37)

-2.717

0.014*

 IVIM_f

0.06(0.05–0.07)

0.05(0.03–0.06)

-1.830

0.080

0.06(0.05–0.07)

0.05(0.03–0.06)

0.05(0.04–0.06)

-1.368

0.205

  1. Values are presented as median (interquartile range). Please note the p values were corrected for multiple comparisons using the Benjamini-Hochberg method. *p < 0.05 and **p < 0.01. Units for nDDVD and IVIM-D values are 10− 3 and 10− 3 mm2/s, respectively. #represents the p value for comparison between glioblastoma and astrocytoma groups. DDVD = diffusion-derived vessel density, IVIM = intravoxel incoherent motion, TP = tumor parenchyma, IDH = isocitrate dehydrogenase