Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas

Table 3 Diagnostic performance of DDVD and IVIM parameter values for IDH genotyping of gliomas

Region/Metrics		DDVD_{b0b10_b10b20}		DDVD_b0b10		nDDVD_{b0b10_b10b20}		nDDVD_b0b10		IVIM_D		IVIM_f
Region/Metrics		AUC	p	AUC	p	AUC	p	AUC	p	AUC	p	AUC	p
Whole TP		0.709	0.008^**	0.577	0.296	0.763	< 0.001^**	0.634	0.080	0.746	0.003^**	0.634	0.080
Tumor habitat
DDVD_{b0b10_b10b20}	Mask1	0.559	0.510	0.588	0.356	0.693	0.027^*	0.501	0.989	0.746	0.006^**	0.587	0.356
	Mask2	0.751	0.002^**	0.615	0.117	0.804	< 0.001^**	0.712	0.005^**	0.735	0.002^**	0.711	0.005^**
DDVD_b0b10	Mask1	0.727	0.004^**	0.587	0.284	0.765	< 0.001^**	0.562	0.401	0.744	0.003^**	0.597	0.279
	Mask2	0.785	< 0.001^**	0.731	0.002^**	0.823	< 0.001^**	0.809	< 0.001^**	0.746	0.001^**	0.779	< 0.001^**
nDDVD_{b0b10_b10b20}	Mask1	0.566	0.445	0.588	0.347	0.638	0.177	0.535	0.630	0.741	0.006^**	0.592	0.347
	Mask2	0.690	0.015^*	0.594	0.201	0.799	< 0.001^**	0.672	0.023^*	0.735	0.003^**	0.704	0.010^*
nDDVD_b0b10	Mask1	0.621	0.149	0.642	0.104	0.729	0.006^**	0.560	0.417	0.726	0.006^**	0.604	0.187
	Mask2	0.731	0.003^**	0.626	0.085	0.808	< 0.001^**	0.769	< 0.001^**	0.739	0.002^**	0.719	0.004^**
IVIM_D	Mask1	0.722	0.004^**	0.612	0.127	0.737	0.003^**	0.641	0.081	0.760	< 0.001^**	0.619	0.125
	Mask2	0.678	0.030^*	0.585	0.298	0.692	0.027^*	0.600	0.260	0.519	0.799	0.710	0.024^*
IVIM_f	Mask1	0.576	0.513	0.570	0.513	0.680	0.042^*	0.531	0.670	0.721	0.018^*	0.532	0.670
	Mask2	0.696	0.016^*	0.571	0.335	0.697	0.016^*	0.618	0.161	0.732	0.012^*	0.608	0.169

Please note the p values were corrected for multiple comparisons using the Benjamini-Hochberg method. ^*p < 0.05 and ^**p < 0.01. DDVD = diffusion-derived vessel density, IVIM = intravoxel incoherent motion, TP = tumor parenchyma, IDH = isocitrate dehydrogenase, AUC = area under curve

ISSN: 1471-2342