Table 1 Summary of included studies
Study/ year | Country | Study design | Time period | Anatomic location of lesions | Case (CEUS/US) | Age (years) | Sex (male/female) | SonoVue dose (mL) | Leision size (cm) | Standard reference test |
|---|---|---|---|---|---|---|---|---|---|---|
Bai 2022 | China | Re-NRCS | 2020–2021 | peripheral lung | 42/38 | 53.18 ± 1.88 | 45/35 | 2.0 | 5.47 ± 1.64 | histology |
Quarato 2021 | Italy | RCT | 2018–2019 | peripheral lung | 116/116 | 65.75 ± 5.45 | 139/93 | 4.8 | 2.74 ± 0.55 | histology |
Mao 2017 | China | Re-NRCS | 2013–2015 | peripheral lung | 121/131 | 59.89 ± 14.93 | 171/81 | 2.4 | ns | histology |
You 2022 | China | RCT | 2016–2021 | peripheral lung | 55/55 | 68.20 ± 13.60 | 73/37 | 2.4 | 4.82 ± 2.46 | histology, clinical follow-up |
Wang 2024 | China | Re-NRCS | 2017–2022 | peripheral lung | 393/634 | 60.09 ± 12.83 | 683/344 | 1.0–2.0 | 6.20 ± 2.79 | histology, clinical follow-up |
Liang 2020 | China | Pro-NRCS | 2016–2018 | peripheral lung | 54/66 | 53.67 ± 14.82 | 86/34 | 2.4 | 3.22 ± 0.20 | histology |
Zhou 2022 | China | Re-NRCS | 2017–2018 | peripheral lung | 190/155 | 58.13 ± 14.56 | 252/93 | 2.4 | 4.38 ± 2.41 | histology |
Zhang 2020 | China | Re-NRCS | ns | peripheral lung | 52/40 | 66.40 ± 12.60 | 56/36 | 2.4 | 3.20 ± 1.10 | histology |
Jiang 2024 | China | Re-NRCS | 2017–2023 | peripheral lung | 118/119 | 68.05 ± 10.30 | 175/62 | 2.4 | 4.25 ± 1.50 | histology |
Fu 2016 | China | Re-NRCS | 2011–2016 | anterior medial mediastinal | 64/51 | 43.96 ± 15.79 | 56/59 | 1.5 | 7.67 ± 2.74 | histology |
Han 2019 | China | Re-NRCS | 2013–2019 | anterior mediastinal | 20/48 | 36.41 ± 14.37 | 42/26 | 2.4 | 10.18 ± 3.09 | histology |
Yi 2017 | China | RCT | 2012–2015 | anterior mediastinal | 45/45 | 38.00 ± 19.47 | 55/35 | 2.4 | 7.41 ± 2.65 | histology |
Fan 2022 | China | Re-NRCS | 2015–2021 | anterior mediastinal | 151/133 | 43.21 ± 18.54 | 166/118 | 2.0 | ns | histology |
Cao 2011 | China | Re-NRCS | 2006–2011 | peripheral lung, mediastinal | 62/59 | 56.31 ± 16.99 | 95/26 | 4.8 | 6.80 ± 2.55 | histology, clinical follow-up |
Wang 2015 | China | Re-NRCS | 2011–2013 | peripheral lung, mediastinal | 82/60 | ns | ns | 2.4 | 6.58 ± 3.06 | histology, clinical follow-up |
Ye 2022 | China | Re-NRCS | 2018–2021 | pleura | 74/70 | 60.76 ± 15.89 | 90/54 | 2.4 | ns | histology |